Effect of atomization inhalation of budesonide and terbutaline sulfate on serum levels of chemokine like factor-1 and cyclooxygenase 2 in children with bronchial asthma
10.3760/cma.j.issn.1008-6706.2019.03.012
- VernacularTitle:布地奈德联合硫酸特布他林雾化吸入对支气管哮喘患儿血清趋化素样因子-1、环氧化酶2水平变化的影响
- Author:
Xiangying WANG
1
;
Ruju XU
Author Information
1. 杭州市儿童医院儿科 310000
- Keywords:
Budesonide;
Terbutaline sulfate;
Asthma;
Chemokine like factor-1;
Cyclooxygenase 2;
Atomization inhalation;
Treatment effect
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(3):298-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of atomization inhalation of budesonide and terbutaline sulfate on serum levels of cyclcoxygenase 2 (COX-2) and chemokine like factor-1 (CKLF-1) in children with bronchial asthma.Methods A total of 78 children with bronchial asthma in Hangzhou Children's Hospital from April 2016 to August 2017 were selected and divided into the control group(n =39) and the study group(n =39).The control group was treated with routine treatment,and the study group was treated with budesonide and terbutaline sulfate on the basis of the control group.The treatment was continued for 7 d.After t treatment,the clinical effects,clinical symptoms improvement,hospitalization time,the serum levels of COX-2 and CKLF-1 before and after treatment,and the incidence of adverse reaction of two groups were observed.Results The total effective rate of the study group(94.87％) was higher than that of the control group (74.36％)(x2 =6.303,P ＜ 0.05).The improvement time of chest tightness,wheezing,cough and hospitalization time of the study group were shorter than those of the control group (t1 =13.054,t2 =7.365,t3 =4.944,t4 =8.342,all P ＜ 0.05).After treatment,the levels of serum COX-2 and CKLF-1 in the two groups were lower than those before treatment,which of the study group were lower than those in the control group(t1 =4.934,t2 =4.660,all P ＜0.05).There was statistically significant difference in the incidence rate of adverse reactions between the study group(12.82％) and the control group(7.69％) (x2 =0.139,P ＞ 0.05).Conclusion Atomization inhalation of budesonide and terbutaline sulfate in the treatment of children with bronchial asthma can effectively alleviate the clinical symptoms,reduce serum levels of COX-2 and CKLF-1,improve therapeutic effect,promote children's recovery and shorten the hospitalization time.Besides,the incidence rate of adverse reactions is low,and it is safe.
