Hyperpolarization activated cyclic nucleotide-gated cation channels involved in central nervous system diseases:research advances

VernacularTitle:超极化激活环核苷酸门控阳离子通道参与中枢神经系统疾病研究进展
Author: Gen-Ji XU ¹ ; Yi-Fan LI ; Shu-Zhuo ZHANG ; Shuang LIU
Author Information

1. 佳木斯大学基础医学院生物学教研室
Keywords: hyperpolarization activated cyclic nucleotide-gated cation (HCN) channels; nervous system diseases; drug addiction
From: Journal of International Pharmaceutical Research 2018;45(8):565-568
CountryChina
Language:Chinese
Abstract: Hyperpolarization activated cyclic nucleotide-gated cation (HCN) channels are involved in neuronal rhythm regulation, synaptic activity, membrane resistance and dendritic integration due to their voltage-gated physiological properties. Recent studies have shown that HCN channels play an important role in central nervous system diseases, such as temporal lobe epilepsy, neuropathic pain, learning and memory disorder, substance abuse addiction and other related diseases. In this paper, we summarize the research progress of HCN channels in central nervous system diseases in recent years.