Effect of interaction between microglia and T cell on brain damage after ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.03.011
- VernacularTitle:小胶质细胞与T细胞的交互作用对缺血性卒中后脑损伤的影响
- Author:
Qiuping LIU
1
;
Xuezhu ZHANG
Author Information
1. 天津中医药大学 301617;天津中医药大学第一附属医院 300192
- Keywords:
Stroke;
Brain ischemia;
Microglia;
T-Lymphocytes;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2019;27(3):223-229
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between microglia and T cells plays an important role in brain injury after ischemic stroke.Unlike helper T cells (Th),regulatory T cells (Treg) are T cell subset with regulatory and immunosuppressive functions,and important regulator of immune response and inflammatory response.Its interaction with microglia provides a potential therapeutic target for the recovery of brain injury after ischemic stroke.Among them,the interaction between M1 microglia and Thl/Thl7 cells promotes immune response and aggravates brain injury after stroke,while the interaction between M2 microglia and Th2/Treg cells inhibits inflammatory response and contributes to the repair of brain injury.
