Progress in the mechanisms of multiple myeloma bone diseases
10.3760/cma.j.issn.1009-9921.2019.03.017
- VernacularTitle:多发性骨髓瘤骨病发生机制研究进展
- Author:
Shiwei YANG
1
;
Zunmin ZHU
Author Information
1. 河南省人民医院血液病研究所 郑州大学人民医院血液科 450003
- Keywords:
Multiple myeloma;
Myeloma bone diseases;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma bone diseases (MMBD) is a series of osteolytic changes caused by plasma cells malignant proliferation,including bone pain,hypercalcemia,osteoporosis,pathological fracture,etc.MMBD has insidious onset,high misdiagnosis rate and poor prognosis.The broken-up bone homeostasis model due to the activated osteoclasts and inhibited osteoblasts is considered as the core mechanism.More and more studies suggest that osteocyte is the key to regulate the activity of osteoclasts and osteoblasts,and the occurrence of MMBD is regulated by some cytokines.This article reviews the mechanisms of MMBD.
