Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection
- Author:
Nani JUNG
1
;
Hye Jin BYUN
;
Jae Hyun PARK
;
Joon Sik KIM
;
Hae Won KIM
;
Ji Yong HA
Author Information
- Publication Type:Original Article
- Keywords: Urinary tract infection; Biomarkers; Neutrophil gelatinase-associated lipocalin
- MeSH: Area Under Curve; Biomarkers; Diagnosis; Early Diagnosis; Fever; Humans; Infant; Lipocalins; Multivariate Analysis; Neutrophils; Retrospective Studies; Sensitivity and Specificity; Urinary Tract Infections; Urinary Tract
- From:Korean Journal of Pediatrics 2018;61(1):24-29
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The aim of this study was to evaluate the diagnostic accuracy of urinary biomarkers, such as neutrophil gelatinase-associated lipocalin (uNGAL) and β-2 microglobulin (uB2MG), in early detection of urinary tract infection (UTI) in infants aged < 3 months with fever. METHODS: A total of 422 infants aged < 3 months (male:female=267:155; mean age, 56.4 days), who were admitted for fever, were retrospectively included in this study. We compared uNGAL and uB2MG between the UTI and non-UTI groups at the time of admission. The sensitivity, specificity, accuracy, and area under the curve (AUC) of uNGAL and uB2MG for use in diagnosing UTI were assessed. RESULTS: Among 422 patients, 102 (24.2%) were diagnosed with UTI. Levels of uNGAL were higher in the UTI group than in the non-UTI group (366.6 ng/mL vs. 26.9 ng/mL, P < 0.001). Levels of uB2MG were not different between the 2 groups. Multivariate analysis revealed that uNGAL was an independent predictive factor for UTI (P=0.033). The sensitivity, specificity, and accuracy were 90.2%, 92.5%, and 91.9% for uNGAL, and 48.0%, 43.8%, and 44.8% for uB2MG, respectively. AUC of uNGAL was 0.942 and that of uB2MG was 0.407. CONCLUSION: Accuracy of uNGAL in the diagnosis of UTI is high in febrile infants aged < 3 months. uNGAL can help in the early diagnosis and treatment of UTI in infants.
