Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients

Author: Ho Seok LEE ¹ ; Woo Jin KIM ; Ji Sun GONG ; Kyoung Ho PARK
Author Information

1. Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. khpent@catholic.ac.kr
Publication Type:Case Report
Keywords: Sensorineural hearing loss; Bone marrow derived mesenchymal stem cell; Electrical stimulation
MeSH: Animals; Bone Marrow; Clinical Study; Electric Stimulation; Hair; Hearing Loss; Hearing Loss, Sensorineural; Hearing; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; Pilot Projects; Spiral Ganglion; Stem Cell Transplantation
From:Journal of Audiology & Otology 2018;22(2):105-109
CountryRepublic of Korea
Language:English
Abstract: Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.