Assessing Seasonality of Acute Febrile Respiratory Tract Infections and Medication Use
	    		
		   		
		   			
		   		
	    	
    	 
    	10.4332/KJHPA.2018.28.4.402
   		
        
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Juhee PARK
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Won Suk CHOI
			        		
			        		;
		        		
		        		
		        		
			        		Hye Yeong LEE
			        		
			        		;
		        		
		        		
		        		
			        		Kyoung Hoon KIM
			        		
			        		;
		        		
		        		
		        		
			        		Dong Sook KIM
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. Pharmaceutical and Medical Device Research Team, Department of Research, Health Insurance Review and Assessment Service, Wonju, Korea. sttone@hira.or.kr
			        		
		        		
	        		
        		 
        	
        	
        	
        		- Publication Type:Original Article
 
        	
        	
        		- Keywords:
        			
	        			
	        				
	        				
			        		
				        		Influenza, Human;
			        		
			        		
			        		
				        		Seasons;
			        		
			        		
			        		
				        		Drug Utilization Review;
			        		
			        		
			        		
				        		Population surveillance
			        		
			        		
	        			
        			
        		
 
        	
            
            	- MeSH:
            	
	        			
	        				
	        				
				        		
					        		Anti-Bacterial Agents;
				        		
			        		
				        		
					        		Antiviral Agents;
				        		
			        		
				        		
					        		Disease Outbreaks;
				        		
			        		
				        		
					        		Drug Utilization Review;
				        		
			        		
				        		
					        		Influenza, Human;
				        		
			        		
				        		
					        		Insurance, Health;
				        		
			        		
				        		
					        		Population Surveillance;
				        		
			        		
				        		
					        		Prescriptions;
				        		
			        		
				        		
					        		Respiratory System;
				        		
			        		
				        		
					        		Respiratory Tract Infections;
				        		
			        		
				        		
					        		Seasons
				        		
			        		
	        			
	        			
            	
            	
 
            
            
            	- From:Health Policy and Management
	            		
	            		 2018;28(4):402-410
	            	
            	
 
            
            
            	- CountryRepublic of Korea
 
            
            
            	- Language:Korean
 
            
            
            	- 
		        	Abstract:
			       	
			       		
				        
				        	BACKGROUND: Monitoring appropriate medication categories can provide early warning of certain disease outbreaks. This study aimed to present a methodology for selecting and monitoring medications relevant to the surveillance of acute respiratory tract infections, such as influenza. METHODS: To estimate correlations between acute febrile respiratory tract infection and some medication categories, the cross-correlation coefficient (CCC) was used and established. Two databases were used: real-time prescription trend of antivirals, anti-inflammatory drugs, antibiotics using Drug Utilization Review Program between 2012 and 2015 and physicians' number of encounters with acute febrile respiratory tract infections such as influenza outbreaks using the national level health insurance claims data. The seasonality was also evaluated using the CCC. RESULTS: After selecting six candidate diseases that require extensive monitoring, influenza with highly specific medical treatment according to the health insurance claims data and its medications were chosen as final candidates based on a data-driven approach. Antiviral medications and influenza were significantly correlated. CONCLUSION: An annual correlation was observed between influenza and antiviral medications, anti-inflammatory drugs. Suitable models should be established for syndromic surveillance of influenza.