Soluble Dipeptidyl Peptidase-4 Levels Are Associated with Decreased Renal Function in Patients with Type 2 Diabetes Mellitus
- Author:
Eun Hee CHO
1
;
Sang Wook KIM
Author Information
- Publication Type:Original Article
- Keywords: Diabetes mellitus, type 2; Dipeptidyl peptidase 4; Glomerular filtration rate; Kidney
- MeSH: Body Mass Index; Calcium; Cholesterol; Coronary Artery Disease; Coronary Vessels; Creatinine; Diabetes Mellitus, Type 2; Diet; Dipeptidyl Peptidase 4; Glomerular Filtration Rate; Humans; Kidney; Retrospective Studies; Waist Circumference
- From:Diabetes & Metabolism Journal 2019;43(1):97-104
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) is strongly expressed in the kidney, and soluble levels of this protein are used as a marker in various chronic inflammatory diseases, including diabetes, coronary artery disease, and cancer. This study examined the association between the serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus. METHODS: In this retrospective analysis, soluble DPP-4 levels were measured in preserved sera from 140 patients with type 2 diabetes mellitus who had participated in our previous coronary artery calcium (CAC) score study. RESULTS: The mean±standard deviation soluble DPP-4 levels in our study sample were 645±152 ng/mL. Univariate analyses revealed significant correlations of soluble DPP-4 levels with the total cholesterol (r=0.214, P=0.019) and serum creatinine levels (r=−0.315, P<0.001) and the estimated glomerular filtration rate (eGFR; estimated using the modification of diet in renal disease equation) (r=0.303, P=0.001). The associations of soluble DPP-4 levels with serum creatinine and GFR remained significant after adjusting for age, body mass index, and duration of diabetes. However, no associations were observed between soluble DPP-4 levels and the body mass index, waist circumference, or CAC score. CONCLUSION: These data suggest the potential use of serum soluble DPP-4 levels as a future biomarker of deteriorated renal function in patients with type 2 diabetes mellitus.
