A New Perspective on the Heterogeneity of Cancer Glycolysis
10.4062/biomolther.2017.210
- Author:
Michael L NEUGENT
1
;
Justin GOODWIN
;
Ishwarya SANKARANARAYANAN
;
Celal Emre YETKIN
;
Meng Hsiung HSIEH
;
Jung Whan KIM
Author Information
1. Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080, USA. jay.kim@utdallas.edu
- Publication Type:Review
- Keywords:
Glycolysis;
Heterogeneity;
Tumor microenvironment;
Stroma;
Metabolism;
Cancer
- MeSH:
Cell Proliferation;
Glucose;
Glycolysis;
Humans;
Metabolism;
Paint;
Plastics;
Population Characteristics;
Stromal Cells;
Tumor Microenvironment
- From:Biomolecules & Therapeutics
2018;26(1):10-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has emphasized a uniformly elevated aerobic glycolysis as a critical feature of tumorigenecity. This led to extensive efforts of targeting glycolysis in human cancers. However, clinical attempts to target glycolysis and glucose metabolism have proven to be challenging. Recent advancements revealing a high degree of metabolic heterogeneity and plasticity embedded among various human cancers may paint a new picture of metabolic targeting for cancer therapies with a renewed interest in glucose metabolism. In this review, we will discuss diverse oncogenic and molecular alterations that drive distinct and heterogeneous glucose metabolism in cancers. We will also discuss a new perspective on how aberrantly altered glycolysis in response to oncogenic signaling is further influenced and remodeled by dynamic metabolic interaction with surrounding tumor-associated stromal cells.
