Brain metastasis from colorectal cancer: a single center experience
10.4174/astr.2018.94.1.13
- Author:
Dong Yeop KIM
1
;
Chun Geun RYU
;
Eun Joo JUNG
;
Jin Hee PAIK
;
Dae Yong HWANG
Author Information
1. Department of Surgery, Colorectal Cancer Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. hwangcrc@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Brain;
Neoplasm metastasis;
Radiosurgeries;
Prognosis
- MeSH:
Ataxia;
Brain;
Colon;
Colorectal Neoplasms;
Diagnosis;
Female;
Headache;
Humans;
Lung;
Male;
Neoplasm Metastasis;
Neurologic Manifestations;
Prognosis;
Radiosurgery;
Rectum;
Retrospective Studies
- From:Annals of Surgical Treatment and Research
2018;94(1):13-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The detection rate of brain metastasis (BM) from colorectal cancer (CRC) is increasing. This study was designed to analyze the clinical features of BM and prognosis according to the therapeutic modalities. METHODS: A total of 19 cases were collected in this study between November 2008 and December 2015. We reviewed the patients' demographic data and the clinical features of BM retrospectively and investigated their prognostic significance. RESULTS: Nineteen patients included 8 male and 11 female patients. The median age at diagnosis of BM was 62.4 years (range, 32–83 years). The median interval between diagnosis of CRC and BM was 39 months (range, 0–98 months). Eighteen patients (94.7%) had extracranial metastasis at the diagnosis of BM. Lung was the most common site of extracranial metastasis in 14 patients (73.7%). Synchronous BMs were found at the diagnosis of primary CRC in 2 patients (10.5%). The location of primary CRC was the colon in 6 patients (31.6%) and the rectum in 13 patients (68.4%). At the diagnosis of BM, 10 patients (52.6%) had a solitary BM. The common neurologic symptoms were headache in 8 cases (42.1%) and ataxia in 6 cases (31.6%). The median survival after the diagnosis of BM was 3 months (range, 1–10 months). The patients who underwent surgery plus stereotactic radiosurgery (SRS) had an improved survival (range, 3–10 months) than the other patients (range, 1–6 months) (P = 0.016). CONCLUSION: In patients with BM from CRC, surgical resection plus SRS might improve survival.
