Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-like Activity: A Case Report
10.9758/cpn.2018.16.1.109
- Author:
So Yeon KIM
1
;
Yoo Hyun UM
;
Sung Chul LIM
;
Jong Hyun JEONG
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. anton3@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Anti-LGI-1 antibody encephalitis;
Neuropsychiatric symptoms;
Steroid therapy
- MeSH:
Adult;
Amnesia;
Diagnosis;
Diagnosis, Differential;
Dihydroergotamine;
Encephalitis;
Glioma;
Humans;
Inflammation;
Limbic Encephalitis;
Male;
Memory;
Memory, Short-Term;
Seizures;
Temporal Lobe
- From:Clinical Psychopharmacology and Neuroscience
2018;16(1):109-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related LE who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded.
