The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
10.3339/jkspn.2018.22.1.17
- Author:
Keum Hwa LEE
1
;
Jae Won YANG
;
Jin Young CHO
;
Joo Yup LEE
;
Eun Kyung LIM
;
Michael EISENHUT
;
Dong Yeon JEONG
;
Johanna STEINGROEVER
;
Jae Il SHIN
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. shinji@yuhs.ac
- Publication Type:Review
- Keywords:
Thymic stromal lymphopoietin (TSLP);
glomerulonephritis;
T-helper type 2 (Th2)-dominant immune response;
TSLP transgenic mice
- MeSH:
Animals;
Cytokines;
Dendritic Cells;
Glomerulonephritis;
Glomerulonephritis, IGA;
Glomerulonephritis, Membranoproliferative;
Kidney;
Mice;
Mice, Transgenic;
Nephritis;
T-Lymphocytes;
Th2 Cells
- From:Childhood Kidney Diseases
2018;22(1):17-21
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
