Effectiveness of rapid hepatitis B vaccination with different vaccine dosages and types in adults
10.3760/cma.j.issn.0254-6450.2017.09.001
- VernacularTitle:不同种类和剂量乙型肝炎疫苗成年人快速免疫效果观察
- Author:
Li NIE
1
;
Xinghuo PANG
;
Zheng ZHANG
;
Jianxin MA
;
Xiuying LIU
;
Qian QIU
;
Yan LIANG
;
Qian LI
;
Wei ZHANG
Author Information
1. 100013,北京市疾病预防控制中心 北京市预防医学研究中心 科研教学管理办公室
- Keywords:
Hepatitis B vaccine;
Effectiveness of immunization;
Rapid immunization schedule
- From:
Chinese Journal of Epidemiology
2017;38(9):1151-1155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of rapid hepatitis B vaccination with different vaccine dosages and types in adults.Methods Adults who were aged ≥20 years,negative in the detections of 5 HBV serum markers or only anti-HBc positive were selected from Chaoyang district of Beijing.They were divided into 4 community-based specific groups and given three doses of 10 μ g HepB-SCY vaccine,20 μ g HepB-SCY vaccine,20 μ g HepB-CHO vaccine and 10 μ g HepB-HPY vaccine respectively at month 0,1,and 2.Their blood samples were collected within 1-2 months after completing the three dose vaccination to test anti-HBs level by using chemiluminesent microparticle immunoassay.A face to face questionnaire survey was conducted,and x2 test,Mantel-Haensel x2 test,Kruskal-Wallis rank test and multiple logistic regression analysis were performed.Results A total of 1 772 participants completed vaccination and observation.Their average age was 48.5 years,and 62.75％ of them were females.The anti-HBs positive rates in the groups of 10 μg HepB-SCY,20 μg HepB-SCY,20 μg HepB-CHO and 10 μg HepB-HPY vaccines were 79.49％,84.34％,82.50％ and 74.15％,respectively (P=0.005),and the geometric mean titers (GMT) were 39.53 mIU/ml,62.37 mIU/ml,48.18 mIU/ml and 33.64 mIU/ml respectively (P=0.025).The overall anti-HBs positive rate and GMT were 79.01％ and 41.18 mIU/ml.The anti-HBs GMT of 4 groups declined with age.The differences in anti-HBs GMT among 4 groups minimized with age.The result of logistic modeling indicated that vaccine type and dosage,age and smoking were associated with anti-HBs statistically after controlling the variables of "only anti-HBc positive or not" and "history of hepatitis B vaccination".Conclusion Hepatitis B vaccination at dosage of 20 tg based on 0-1-2 month rapid schedule could achieved anti-HBs positive rates ＞80％ in middle aged and old people,which can be used as supplement of 0-1-6 month routine schedule.
