Correlation between high risk type human papillomavirus E6/E7 mRNA and cervical cancer
10.3760/cma.j.issn.0254-6450.2016.07.019
- VernacularTitle:高危型HPV E6/E7 mRNA与宫颈癌相关性分析
- Author:
Xiaohong WANG
1
;
Yimei QIAN
;
Ling MIAO
;
Yao LE
;
Juan DU
Author Information
1. 解放军第一○一医院妇产科
- Keywords:
Human papillomavirus;
Cervical cancer;
Correlation
- From:
Chinese Journal of Epidemiology
2016;37(7):1003-1005
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the positive rate of high risk human papillomavirus (HPV) mRNA E6/E7 and cervical cancer,and provide evidence for the prevention and treatment of cervical cancer.Methods A total of 100 cervical cancer cases and 100 healthy controls were selected in our hospital from January 2015 to December 2015.The fluorescence quantitative PCR and pathological examination on HPV E6/E7 mRNA were carried out.The correlation between HPV E6/E7 mRNA and cervical squamous epithelial lesions were analyzed.Results In case group,the positive rate ofHPV E6/E7 mRNA was 76.0％ (76/100).In control group,the positive rate was 13.0％ (13/100).The positive rate in case group was significantly higher than that in control group,and the difference was statistically significant (x2=24.522,P＜0.001).The positive predictive value and negative predictive value of the two groups were compared,and the difference was not significant (P＞0.05).The positive rate of HPV E6/E7 mRNA was significantly higher than high-grade squamous intraepithelial lesion (SIL) rate (26.1％),low-grade SIL rate (17.6％) and atypical squamous cell hyperplasia rate (6.7％),the difference was statistically significant (x2=7.615,P=0.001;x2=9.114,P=0.001;x2=18.241,P＜0.001).Conclusions The detection rate ofHPV E6/E7 mRNA in cervical cancer patients was high.And with the increased severity of cervical squamous epithelial lesions,the positive rate of HPV E6/E7 mRNA increased.
