A nested case-control study in studying the relationship between interleukin-6,endothelin-1, E-selectin and the risk of cardio-cerebrovascular events
10.3760/cma.j.issn.0254-6450.2014.10.017
- VernacularTitle:白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究
- Author:
Qiuyan CHEN
1
;
Xiaoqing BU
;
Yan LIU
;
Juan XU
;
Fanlong KONG
;
Guiyan WANG
;
Yonghong ZHANG
Author Information
1. 215123,苏州大学医学部公共卫生学院流行病与卫生统计学教研室
- Keywords:
Cardio-cerebrovascular diseases;
Inflammation;
Strength of association;
Nested case-control study
- From:
Chinese Journal of Epidemiology
2014;(10):1151-1154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between interleukin-6(IL-6),endothelin-1 (ET-1),E-selectin and the risk of cardio-cerebrovascular events. Methods Based on a cohort study in which 2 589 Mongolians had been followed up for 10 years,a nested case-control study was carried out to analyze the relationship between IL-6, ET-1, E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio(OR) and 95%confidence intervals(95%CI). Results The average level of IL-6(7.66 vs. 8.77 pg/ml), ET-1(0.74 vs. 0.75 pg/ml) and E-selectin (17.96 vs. 18.32 ng/ml) were not significantly different between the case and the control groups(P>0.05). Data from the logistic regression analysis showed that IL-6,ET-1 and E-selectin were not significantly associated with the risk of cardio-cerebrovascular events. The multivariable adjusted ORs(95%CI)on the risk of cardio-cerebrovascular events were 0.69 (0.41-1.16),1.10 (0.66-1.85) and 1.19(0.71-2.00) for the participants with IL-6>23.91 pg/ml ,ET-1>1.33 pg/ml and E-selectin>24.43 ng/ml,respectively,compared with those having IL-6≤23.91 pg/ml ,ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml. Conclusion Data from our study indicated that the levels of IL-6,ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia.
