Biomechanical effect of hyaluronidase on rabbit auricular cartilage
10.3760/cma.j.issn.1671-0290.2018.06.006
- VernacularTitle:透明质酸酶对兔耳软骨组织生物力学的影响
- Author:
Changyuan GAO
1
;
Chen ZHANG
;
Fusheng LIU
;
Zhanjun LEI
;
Yuejun LI
Author Information
1. 116622,大连大学整形外科研究所
- Keywords:
Ear cartilage;
Biomechanical phenomena;
Rabbits;
Glycosaminoglycans;
Hyaluronidase
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2018;24(6):404-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the biomechanical effectiveness of hyaluronidase (HAase) on rabbit auricular cartilage in the early stage.Methods HAase in 3 different concentrations (75 U/ml,150 U/ml,300 U/ml) were injected subcutaneously to rabbit auricle in 3 groups,while normal saline were injected as control.For the comparison of biomechanism properties among different groups and different time,cartilages were harvested at 3rd and 7th day after injection,followed by stress-relaxation assay.Results Auricular cartilage displayed different levels in control group compared with other groups in elastic modulus (P＜0.05) and maxmum stress (P＜0.05) in 3th day as well as 7th day.While both in the same concentration group,there were also differences between the 3th and 7th day (P＜0.05).Conclusions HAase injection can cause changes in biomechanical properties of auricular cartilage.And 7 days would not be enough for the tissue recovery biomechanically.
