Research progress on palmitoylation of postsynaptic density protein 95
10.3760/cma.j.issn.0254-9026.2018.12.032
- VernacularTitle:突触后致密蛋白 95 棕榈酰化修饰的研究进展
- Author:
Yinghan ZHANG
1
;
Honghong ZHANG
;
Eryan KONG
;
Zhongjian ZHANG
;
Xiaoning WANG
Author Information
1. 453003,新乡医学院神经精神医学研究院
- Keywords:
Synaptses;
Proteins;
N-Methylaspartiate;
Isoxazoles
- From:
Chinese Journal of Geriatrics
2018;37(12):1423-1427
- CountryChina
- Language:Chinese
-
Abstract:
Postsynaptic density protein 95(PSD-95) ,the most abundant and significant synapse scaffolding protein at excitatory synapses ,is a hallmark of synaptic function. Proteins palmitoylation is one of the important post-translational modifications ,which is occurred more frequently in the nervous system than in other organs. Palmitoylation-dependent regulation of PSD-95 has become a research hotspot in the fields of neuroplasticity and neuropsychiatric diseases.
