Progress in manganese superoxide dismutase in tumor development
10.11904/j.issn.1002-3070.2018.06.016
- VernacularTitle:锰超氧化物歧化酶在肿瘤发生发展过程中的研究进展
- Author:
Qisheng GU
1
Author Information
1. 上海交通大学附属第一人民医院 上海 200080
- Keywords:
Manganese superoxide dismutase;
Reactive oxygen species;
Neoplasms
- From:
Practical Oncology Journal
2018;32(6):562-566
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen is closely related to the occurrence and development of tumors. Manganese superoxide dismutase (MnSOD),as an antioxidant enzyme that scavenges superoxide anion in the mitochondrial matrix,plays an important role in maintai-ning mitochondrial redox homeostasis and protecting mitochondrial DNA. Many studies have discovered that MnSOD has different ex-pression levels in different tumors,and has both anti-cancer and cancer-promoting functions,but its functional conversion mecha-nism remains unclear. This article intends to investigate the role of MnSOD in tumorigenesis and development,and to review the main regulatory mechanisms of its expression level and activity.
