Effects of interleukin-21 ,interleukin-23 and interleukin-4 on the pathogenesis of Guillain-Barré syndrome and the influence of intravenous immunoglobulin
10.3969/cma.j.issn.2095-428X.2013.19.019
- VernacularTitle:吉兰-巴雷综合征患儿血清白细胞介素-21、白细胞介素-23和白细胞介素-4的变化及免疫球蛋白对其的影响
- Author:
Hui LI
1
;
Hai-Luo LIU
;
Yu-Xing GAO
;
Shu-Lan LI
;
Ai-Hua MA
;
Jia-Shui XI
;
Xin-Ying ZHANG
Author Information
1. 山东大学附属省立医院小儿神经科
- Keywords:
Guillain-Barré syndrome;
Interleukin-21;
Interleukin-23;
Interleukin-4;
Intravenous immunoglobulin
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(19):1507-1509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of IL-21,IL-23 and IL-4 in the pathogenesis of Guillain-Barré syndrome(GBS) of children,and to analyze the influence of intravenous immunoglobulin(IVIG) on the serum levels of IL-21,IL-23 and IL-4 in GBS patients.Methods Forty-one pediatric patients with GBS hospitalized in our department from Jan.2005 to Sep.2012 were studied.According to the time of IVIG administration,patients were divided into group A and group B,given IVIG respectively within the 7th day and the 8th-12th day.According to Hughes score,patients were divided into mild group and severe group.The serum levels of IL-21,IL-23 and IL-4 were detected by means of ELISA before and after treatment.Results Before treatment,the serum levels of IL-21,IL-23 and IL-4 had no signifiant difference between group A and group B.After treatment,the serum levels of IL-21,IL-23 in group A and group B were significantly decreased than those before treatment (all P ＜ 0.05),with no significant difference in IL-4 levels.There was no signifiant difference in group A and group B in the serum levels of IL-21,IL-23 and IL-4 after treatment (all P ＞0.05).In the severe group,the serum levels of IL-21,IL-23 were significantly higher than those in the mild group before and after treatment (all P ＜ 0.05),with no significant difference in IL-4 levels.After treatment,the serum levels of IL-21,IL-23 were significantly decreased than those before treatment in the mild group and the severe group (all P ＜ 0.05),with no significant difference in IL-4 levels.Conclusions The serum levels of IL-21,IL-23 are significantly increased in GBS children,indicating they play an important role in the pathogenesis of GBS.Levels of IL-21 and IL-23 are significantly decreased after administration of IVIG,which showed that IVIG could inhibit the secretion of IL21 and IL-23,reduce cellular inflammatory response,and eventually prevent the development of GBS.IL-4 secretion is not obviously affected with IVIG,it might have a role in the recovery of GBS.
