Quality control study of borneol and artificial musk in Xinfufang-Zhenzhusan and Xinfufang-Zhenzhugao
10.3760/cma.j.issn.1673-4246.2018.11.016
- VernacularTitle:新复方珍珠散及其膏剂的质量控制研究
- Author:
Zixuan DU
1
;
Yangming DING
;
Ya'nan LI
;
Yibo WANG
;
Xingbing YIN
;
Aihua WANG
;
Zheng LIU
;
Xin FENG
;
Jian NI
Author Information
1. 100102,北京中医药大学中药学院
- Keywords:
Chromatography,thin layer;
Chromatography,Gas;
Borneolum syntheticum;
Artificial musk;
Isoborneol;
Borneol;
Muscone;
Quality control
- From:
International Journal of Traditional Chinese Medicine
2018;40(11):1070-1074
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a quality control method for bomeol and artificial musk in Xinfufang-Zhenzhusan and Xinfufang-Zhenzhugao.Methods We used petroleum ether-toluene-ethyl acetate (9:3:2)as developer for TLC to identify isoborneol and borneol and petroleum ether-dichloromethane (2:3) as developer for TLC to identificate musk ketone.Agilent 7890 B gas chromatograph,FDI detector;Column:Thermo-TG-WaxMS GC (0.25 mm × 30 m,0.25 mm) was employed;the carrier gas was high purity nitrogen and flow rate for 1 mg/ml,the injection port temperature is 200 C and detector temperature is 250 ℃;the split ratio is 10:1 and injection volume was 1 μl,using temperature programmed.Results The isoborneol,borneol and musk ketone in the range of 0.001-10 mg/ml showed good linearity.The recovery of the method is in the range of 95 ％ to 105 ％.The TLC for isobomeol,bomeol,musk ketone can be identified easily.Conclusions The method was simple and reasonable,which can be used for the quality control of borneol and artificial musk in the Xinfufang-Zhenzhusan and Xinfufang-Zhenzhugao.
