Neuroprotective effect of lipopolysaccharide preconditioning on cerebral ischemia and its mechanism
10.3760/cma.j.issn.1673-4165.2018.11.012
- VernacularTitle:脂多糖预处理对脑缺血的神经保护作用及其机制
- Author:
Zengli WANG
1
;
Hui HAN
Author Information
1. 150001,哈尔滨医科大学附属第一医院老年医学科
- Keywords:
Brain Ischemia;
Reperfusion Injury;
Ischemic Preconditioning;
Lipopolysaccharides;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2018;26(11):865-869
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemic preconditioning can make the brain tissue resistant to subsequent ischemic injury,i.e.ischemic tolerance,thereby reducing ischemia-reperfusion injury.A large number of studies have shown that lipopolysaccharide preconditioning can exert neuroprotective effects against cerebral ischemic injury by initiating endogenous protective mechanisms.This article reviews the cellular and molecular mechanisms of lipopolysaccharide preconditioning induced cerebral ischemic tolerance.
