The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage.
- Author:
Wol Soon JO
1
;
Yoo Jin CHOI
;
Hyoun Ji KIM
;
Jae Yun LEE
;
Byung Hyouk NAM
;
Jae Dong LEE
;
Sang Wha LEE
;
Su Yeong SEO
;
Min Ho JEONG
Author Information
1. Department of Microbiology, Dong-A University College of Medicine, Busan 604-714, Korea. mhjeong@dau.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Anti-inflammatory activity;
Cordyceps militaris;
Lipopolysaccharide;
Nitric oxide;
Pro-inflammatory cytokines;
RAW 264.7 cell
- MeSH:
Cordyceps;
Fruit;
Interleukin-6;
Macrophages;
Nitric Oxide;
Tumor Necrosis Factor-alpha;
Water
- From:Mycobiology
2010;38(1):46-51
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-alpha and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.
