Research progress on metabolic pathway of adenosine and regulation of pro-inflammatory cytokines in cell injury
10.7507/1007-4848.201803002
- VernacularTitle:细胞损伤中腺苷代谢通路与促炎因子调控的研究进展
- Author:
SU Xiaoyang
1
;
LI Shaobin
1
;
YAN Yusheng
1
Author Information
1. Department of Cardiothoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, P.R.China
- Publication Type:Journal Article
- Keywords:
Ischemia-reperfusion injury;
adenosine triphophate;
adenosine;
inflammation
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2018;25(12):1091-1095
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine triphophate (ATP), substantially liberated from the injured cells, activates the inflammatory cells to secrete various inflammatory factors, thus triggering uncontrolled systemic inflammatory response and thrombosis with aggravating the degree of damage. Metabolic pathway of adenosine consists of adenosine (Ado) synthase CD39-CD73, nucleoside transporters (NTs) and termination system of adenosine deaminase (ADA) and adenosine kinase (ADK). As a " switch” of the inflammatory response, the metabolic pathway converts ATP (the pro-inflammatory cytokines) to Ado (the anti-inflammatory mediators), maintaining the homeostasis between pro-inflammatory and anti-inflammatory as well as affecting the outcome of the injury. This review focused on the recent progress of adenosine metabolic pathway in cell injury.
