The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice.
10.4196/kjpp.2008.12.6.343
- Author:
Ho Sun SONG
1
;
Tae Wook PARK
;
Uy Dong SOHN
;
Yong Kyoo SHIN
;
Byung Chul CHOI
;
Chang Jong KIM
;
Sang Soo SIM
Author Information
1. Department of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea. simss@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Caffeic acid;
Histamine;
Arachidonic acid;
Collagen;
Wound healing
- MeSH:
Animals;
Arachidonic Acid;
Caffeic Acids;
Cell Culture Techniques;
Collagen;
Dinoprostone;
Fibroblasts;
Hand;
Histamine;
Histamine Release;
Lipid Peroxidation;
Melitten;
Mice;
Peroxidase;
Phospholipases A2;
Polymers;
Reactive Oxygen Species;
Wound Healing
- From:The Korean Journal of Physiology and Pharmacology
2008;12(6):343-347
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase A2 activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and PGE2 production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.
