Heat Acclimatization in Hot Summer for Ten Weeks Suppress the Sensitivity of Sweating in Response to Iontophoretically-administered Acetylcholine.
10.4196/kjpp.2008.12.6.349
- Author:
Jeong Beom LEE
1
Author Information
1. Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan 330-090, Korea. leejb@sch.ac.kr
- Publication Type:Original Article
- Keywords:
Heat acclimatization;
Sweating;
QSART;
ACh
- MeSH:
Acclimatization;
Acetylcholine;
Axons;
Hot Temperature;
Iontophoresis;
Nerve Fibers, Unmyelinated;
Neurotransmitter Agents;
Receptors, Cholinergic;
Reflex;
Sweat;
Sweating;
Weather
- From:The Korean Journal of Physiology and Pharmacology
2008;12(6):349-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
To determine the peripheral mechanisms involved in thermal sweating during the hot summers in July before acclimatization and after acclimatization in September, we evaluated the sweating response of healthy subjects (n=10) to acetylcholine (ACh), a primary neurotransmitter involved in peripheral sudomotor sensitivity. The quantitative sudomotor axon reflex test (QSART) measures sympathetic C fiber function after iontophoresed ACh evokes a measurable reliable sweat response. The QSART, at 2 mA for 5 min with 10% ACh, was applied to determine the directly activated (DIR) and axon reflex-mediated (AXR) sweating responses during ACh iontophoresis. The AXR sweat onset-time by the axon reflex was 1.50+/-0.32 min and 1.84+/-0.46 min before acclimatization in July and after acclimatization in September, respectively (p<0.01). The sweat volume of the AXR(1) [during 5 min 10% iontophoresis] by the axon reflex was 1.45+/-0.53 mg/cm2 and 0.98+/-0.24 mg/cm2 before acclimatization in July and after acclimatization in September, respectively (p<0.001). The sweat volume of the AXR(2) [during 5 min post-iontophoresis] by the axon reflex was 2.06+/-0.24 mg/cm2 and 1.39+/-0.32 mg/cm2 before and after acclimatization in July and September, respectively (p<0.001). The sweat volume of the DIR was 5.88+/-1.33 mg/cm2 and 4.98+/-0.94 mg/cm2 before and after acclimatization in July and September, respectively (p<0.01). These findings suggest that lower peripheral sudomotor responses of the ACh receptors are indicative of a blunted sympathetic nerve response to ACh during exposure to hot summer weather conditions.
