Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain.
- Author:
Han Jung CHAE
1
;
Jang Sook KANG
;
Seoung Bum CHO
;
Byung Gwan JIN
;
Suk Jun WON
;
Byung Joo GWAN
;
Hyung Ryong KIM
Author Information
1. Department of Dental Pharmacology, Wonkwang University School of Dentistry, Iksan, Chonbuk, 570-749 South Korea.
- Publication Type:Original Article
- Keywords:
Transcription factor;
c-fos mRNA and protein;
Neurotoxicity
- MeSH:
Adult*;
Amygdala;
Animals;
Brain*;
Hippocampus;
Humans;
In Situ Hybridization;
Injections, Intraperitoneal;
Kainic Acid;
Lidocaine*;
Neostriatum;
Neurons;
Prosencephalon;
Rats*;
RNA, Complementary;
RNA, Messenger*;
Seizures;
Transcription Factors
- From:The Korean Journal of Physiology and Pharmacology
1999;3(1):69-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using (35S)UTP-labeled antisense c-fos, cRNA increased c-fos mRNA levels though hippocampal formation, piriform cortex, septum, caudate-putamen, neostriatum, and amygdala within 2 hr. In parallel with the mRNA expression, c-FOS protein immunoreactivity was also observed in the same forebrain areas. In contrast to the seizure activity and widespread neuronal degeneration following a kainate treatment, injections of lidocaine did not produce neuronal death within 3 days. The present study indicates that lidocaine induces convulsion and c-fos expression without causing neuro-toxicity.
