Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L..
10.4196/kjpp.2015.19.1.21
- Author:
Wan Su KIM
1
;
Woo Jin CHOI
;
Sunwoo LEE
;
Woo Joong KIM
;
Dong Chae LEE
;
Uy Dong SOHN
;
Hyoung Shik SHIN
;
Wonyong KIM
Author Information
1. Department of Periodontology, College of Dentistry, Wonkwang University, Iksan 570-749, Korea.
- Publication Type:Original Article
- Keywords:
Anti-inflammatory effect;
Anti-microbial activity;
Antioxidant activity;
Artemisinin
- MeSH:
Acetone;
Aggregatibacter actinomycetemcomitans;
alpha-Tocopherol;
Artemisia annua*;
Dinoprostone;
Ethanol;
Fusobacterium nucleatum;
Interleukin-6;
Methanol;
Nitric Oxide;
Pharmaceutical Preparations;
Prevotella intermedia;
Stomatognathic Diseases;
Water
- From:The Korean Journal of Physiology and Pharmacology
2015;19(1):21-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1beta , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0+/-3.2%), similar to alpha-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
