Attunement Disorder : A Disorder of Brain Connectivity.
- Author:
Ki Won KIM
1
;
Kyung Min PARK
;
Hye Ryeon JANG
;
Yu Sang LEE
;
Seon Cheol PARK
Author Information
1. Department of Psychiatry, Yong-In Mental Hospital, Yongin, Korea. cogito-ergo-sum@hanmail.net
- Publication Type:Review
- Keywords:
Schizophrenia;
Brain connectivity;
Neurodevelopment
- MeSH:
Brain*;
Metaphor;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2013;20(4):136-143
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia. METHOD: We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia. RESULTS: The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as 'a misconnection syndrome of neural circuit or neural network'. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process. CONCLUSION: Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.
