Relationship between Erectile Dysfunction, Comorbidity, and Parkinson's Disease: Evidence from a Population-Based Longitudinal Study.
10.3988/jcn.2017.13.3.250
- Author:
Yuwan YANG
1
;
Hsinho LIU
;
Tienhuang LIN
;
Yuhung KUO
;
Tengfu HSIEH
Author Information
1. Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
- Publication Type:Original Article
- Keywords:
comorbidity;
diabetes;
erectile dysfunction;
Parkinson's disease;
risk
- MeSH:
Cohort Studies;
Comorbidity*;
Diagnosis;
Erectile Dysfunction*;
Humans;
Hypertension;
Incidence;
Longitudinal Studies*;
Male;
National Health Programs;
Parkinson Disease*;
Taiwan
- From:Journal of Clinical Neurology
2017;13(3):250-258
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: To determine the risk of Parkinson's disease (PD) in relation to erectile dysfunction (ED) based on the National Health Insurance Research Database in Taiwan. METHODS: We identified 3,153 patients who were newly diagnosed with ED between January 1, 2004 and December 31, 2010. A total of 12,612 randomly selected people without ED served as healthy controls. All of the study subjects were followed-up from the index date to the date of PD diagnosis, withdrawal from the National Health Insurance program, or the end of 2012 whichever occurred first. RESULTS: The incidence density rate of PD was 1.52-fold higher in the ED cohort than the non-ED cohort (3.44 vs. 1.64 per 1,000 person-years), with an adjusted hazard ratio (HR) of 1.52 [95% confidence interval (CI)=1.09–2.12]. The combined effects on patients with ED and diabetes as well as hypertension showed a significant combined association with the PD risk compared with patients without ED, counterpart comorbidities, or medication use. The adjusted HR of PD for ED was higher for diabetes (2.82, 95% CI=1.42–5.63) and hypertension (2.19, 95% CI = 1.35–3.55). CONCLUSIONS: ED leads to an increased risk of PD. ED patients with diabetes or hypertension have an elevated risk of PD.
