A Case of Autoimmune Hemolytic Anemia Developed in Chronic Lobular Hepatitis B.
- Author:
Heoy Seung KANG
1
;
Hee Young LEE
;
Yoo Seok KIM
;
Ki Seub LEE
;
Byung Il KIM
;
Yun Chul YIE
;
Jung Ho LEE
;
Myeung Rae LEE
;
Dong Il BYUN
;
Mi Yae YOON
;
Soo Nam LEE
Author Information
1. Department of Internal Medicine, Incheon Christian Hospital, Incheon, Korea.
- Publication Type:Case Report
- Keywords:
Autoimmune hemolytic anemia;
Chronic lobular hepatitis
- MeSH:
Adult;
Anemia, Hemolytic;
Anemia, Hemolytic, Autoimmune*;
Biopsy;
Blood Cell Count;
Bone Marrow;
Cell Membrane;
Coombs Test;
Diagnosis;
Follow-Up Studies;
Hemolysis;
Hepatitis B*;
Hepatitis*;
Humans;
Hypersplenism;
Immunoglobulins;
Liver;
Liver Failure;
Liver Function Tests;
Male;
Urinalysis
- From:Korean Journal of Hematology
1998;33(2):256-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although a pathogenic mechanism of hemolytic anemia complicated with viral hepatitis is unknown, it is suggested that there are four mechanisms; 1) In the individual who has predisposition to hemolytic anemia, viral infection accelerates the red cell destruction & hemolysis become obvious. 2) Directly, virus itself injures to the red cell membrane. 3) The serious liver failure & hypersplenism induce the hemolysis. 4) Autoimmune hemolytic anemia because of immunological abnormality caused by viral infection. We experienced a case of autoimmune hemolytic anemia in 33-year-old male patient who was diagnosed as chronic lobular hepatitis B with biopsy. Diagnosis was estabilished by clinical features, blood cell count, routine urinalysis, direct & indirect Coombs test, liver function test, immunoglobulin quantitations, hepatitis B marker, bone marrow aspiration, and liver biopsy. This case was treated with corticosteroid and transfusion. During follow-up, he has been well tolerated.
