Hematopoietic Stem Cell Transplantation with Using Multinational Unrelated Donors for Acute Myelogenous Leukemia.
- Author:
Hee Je KIM
1
;
Woo Sung MIN
;
Ki Seong EOM
;
Byung Sik CHO
;
Sung Yong KIM
;
Ji Na BOK
;
Kwang Sung KIM
;
Chang Ki MIN
;
Seok LEE
;
Seok Goo CHO
;
Dong Wook KIM
;
Jong Wook LEE
;
Chun Choo KIM
Author Information
- Publication Type:Original Article
- Keywords: Multinational unrelated donor; HSCT; AML; GvHD
- MeSH: Bone Marrow; Cyclophosphamide; Cytogenetics; Disease-Free Survival; Follow-Up Studies; Hematopoietic Stem Cell Transplantation*; Hematopoietic Stem Cells*; Humans; Incidence; Japan; Leukemia, Myeloid, Acute*; Methotrexate; Mortality; Tacrolimus; Taiwan; Tissue Donors; Unrelated Donors*
- From:Korean Journal of Hematology 2007;42(2):98-105
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Many AML patients have received hematopoietic stem cell transplantation (HSCT) from HLA-matched unrelated donors. According to many of the previous reports, those patients could achieve long-term, disease-free survival after HSCT from multinational unrelated donors with tolerable transplant-related complications, even when there are HLA-mismatches. METHODS: We present the results of 35 unrelated hematopoietic stem cell transplantations from multiple international donor banks including the Korean (n=24), and Japan Marrow Donor Program (n=3), the Taiwan Tzu Chi Marrow Donation Registry (n=6), as well as using Caucasian donors from the National Marrow Donor Program (n=2), for the treatment of AML patients. RESULTS: The median age of patients was 36 (range: 16~53) and the median follow-up duration was 21 months (range: 5~60). Also, the median age of the donors was 28 (range: 20~53). The majority of the patients had intermediate or unfavorable cytogenetic features. The main conditioning regimen we used consisted of cyclophosphamide plus TBI (n=31) with our standard GvHD prophylaxis that contained tacrolimus plus a short course of methotrexate. Some patients (n=10) received an additional two-day course of ATG (thymoglobulin, Sangstat) in addition to the standard regimen. All the transplanted patients achieved engraftment. The incidence of acute GvHD was 42%, and that of chronic GvHD was 56%. Four (11%) patients have relapsed to date. The two-year non-relapse transplant-related mortality was 26%. The estimated probability of DFS and the event-free survival at five-years were 80% and 53%, respectively. CONCLUSION: These results suggest that multinational unrelated donors HSCT may provide a feasible option for the treatment of high-risk Korean AML patients.
