Comparison of the Serum Cholesterol, Insulin Resistance and Markers of Metabolic Syndrome Based on Hepatitis C Virus RNA.
10.5393/JAMCH.2016.41.4.205
- Author:
Sung Hwan CHO
1
;
Yun Jin KIM
;
Sang Yeoup LEE
;
Byung Mann CHO
;
Hye Lim HWANG
;
Yu Hyeon YI
;
Young Hye CHO
;
Young Jin TAK
;
Dong Wook JEONG
;
Seung Hun LEE
;
Jeong Gyu LEE
Author Information
1. Department of Family Medicine, Pusan National University School of Medicine, Korea. jeklee@pnu.edu
- Publication Type:Original Article
- Keywords:
Hepatitis C;
Insulin resistance;
Metabolic syndrome
- MeSH:
Adult;
Anthropometry;
Blood Glucose;
Blood Pressure;
Busan;
Cholesterol*;
Cholesterol, HDL;
Cholesterol, LDL;
Cohort Studies;
Cross-Sectional Studies;
Fasting;
Health Promotion;
Hepacivirus*;
Hepatitis C*;
Hepatitis*;
Humans;
Insulin Resistance*;
Insulin*;
Plasma;
Prospective Studies;
RNA;
Triglycerides;
Waist Circumference
- From:Journal of Agricultural Medicine & Community Health
2016;41(4):205-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We compared the difference of lipid, insulin resistance and metabolic markers based on HCV RNA in Korean adults. METHODS: This was a cross-sectional study of 222 subjects visited the health promotion center of Pusan national university hospital from 2004 to 2007. Subjects were anti-HCV antibody positive and were performed RT-PCR for HCV RNA. The HCV RNA (+) group were 85 subjects, HCV RNA (−) control group were 115 subjects, and the HCV RNA (−) but past positive group were 22 subjects. We performed anthropometry, anti-HCV, RT-PCR, plasma concentrations of insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglyceride. RESULTS: BMI, waist circumference, blood pressure, fasting plasma glucose, triglyceride, HDL cholesterol, insulin resistance such as HOMA-IR and QUICKI were not significantly different between HCV RNA positive and negative groups. The serum total cholesterol and LDL cholesterol level were significantly lower in the HCV RNA positive group than in the negative group (186.24±37.63 vs 197.22±37.23 mg/dl, p=0.041, 111.66±34.06 vs 121.38±35.50 mg/dl, p=0.042). After adjusting age and sex, high total cholesterol (≥ 200mg/dl) (adjusted OR=0.51, 95%CI 0.28-0.94, p=0.03) and high LDL cholesterol (≥ 130mg/dl) (adjusted OR=0.46, 95%CI 0.24~0.87, p=0.02) were inversely associated with being HCV RNA positive (p<0.05). CONCLUSIONS: The serum total cholesterol and LDL-cholesterol level were significantly lower in HCV RNA (+) group than in HCV RNA (−) group, but not in HCV RNA (−) but past positive group. Prospective cohort studies are needed to clarify the relationship between HCV RNA and metabolic markers.
