Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies.
10.3803/EnM.2018.33.4.473
- Author:
Shinje MOON
1
;
Hye Soo CHUNG
;
Jae Myung YU
;
Hyung Joon YOO
;
Jung Hwan PARK
;
Dong Sun KIM
;
Young Joo PARK
Author Information
1. Division of Endocrinology and Metabolism, Hallym University College of Medicine, Chuncheon, Korea.
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Hashimoto disease;
Thyroid cancer, papillary;
Prognosis
- MeSH:
Epidemiologic Studies;
Hashimoto Disease*;
Humans;
Lymph Nodes;
Methods;
Neoplasm Metastasis;
Odds Ratio;
Population Characteristics;
Prognosis;
Recurrence;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Endocrinology and Metabolism
2018;33(4):473-484
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC. METHODS: We searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method. Additionally, the Higgins I 2 statistic was used to test for heterogeneity. RESULTS: The meta-analysis included 71 published studies with 44,034 participants, among whom 11,132 had HT. We observed negative associations between PTC with comorbid HT and extrathyroidal extension (OR, 0.74; 95% CI, 0.68 to 0.81), lymph node metastasis (OR, 0.82; 95% CI, 0.72 to 0.94), distant metastasis (OR, 0.49; 95% CI, 0.32 to 0.76), and recurrence (RR, 0.50; 95% CI, 0.41 to 0.61). CONCLUSION: In this meta-analysis, PTC patients with HT appeared to exhibit more favorable clinicopathologic characteristics and a better prognosis than those without HT.
