¹⁸FFET PET is a useful tool for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic glioblastoma mouse model.
10.5625/lar.2018.34.4.248
- Author:
Ok Sun KIM
1
;
Jang Woo PARK
;
Eun Sang LEE
;
Ran Ji YOO
;
Won Il KIM
;
Kyo Chul LEE
;
Jae Hoon SHIM
;
Hye Kyung CHUNG
Author Information
1. Korea Drug Development Platform using Radio-isotope, Korea Institute of Radiological & Medical Sciences, Seoul, Korea. hkchung@kirams.re.kr
- Publication Type:Original Article
- Keywords:
[¹⁸F]FET PET;
glioblastoma;
bevacizumab;
anti-angiogenic drug;
orthotopic model
- MeSH:
Animals;
Bevacizumab;
Electrons;
Glioblastoma*;
Humans;
Magnetic Resonance Imaging;
Methods;
Mice*;
Mice, Nude;
Prognosis*
- From:Laboratory Animal Research
2018;34(4):248-256
- CountryRepublic of Korea
- Language:English
-
Abstract:
O-2-¹⁸F-fluoroethyl-l-tyrosine ([¹⁸F]FET) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to examine the value of [¹⁸F]FET for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic mouse model of GBM. Human U87MG cells were implanted into nude mice and then bevacizumab, a representative anti-angiogenic drug, was administered. We monitored the effect of anti-angiogenic agents using multiple imaging modalities, including bioluminescence imaging (BLI), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET/CT). Among these imaging methods analyzed, only [¹⁸F]FET uptake showed a statistically significant decrease in the treatment group compared to the control group (P=0.02 and P=0.03 at 5 and 20 mg/kg, respectively). This indicates that [¹⁸F]FET PET is a sensitive method to monitor the response of GBM bearing mice to anti-angiogenic drug. Moreover, [¹⁸F]FET uptake was confirmed to be a significant parameter for predicting the prognosis of anti-angiogenic drug (P=0.041 and P=0.007, on Days 7 and 12, respectively, on Pearson's correlation; P=0.048 and P=0.030, on Days 7 and 12, respectively, on Cox regression analysis). However, results of BLI or MRI were not significantly associated with survival time. In conclusion, this study suggests that [¹⁸F]FET PET imaging is a pertinent imaging modality for sensitive monitoring and accurate prediction of treatment response to anti-angiogenic agents in an orthotopic model of GBM.
