Multiple Microvenular Hemangioma Clinicopathologically Mimicking Early Stage Kaposi Sarcoma: A Case Report.
- Author:
Dong Hyuk EUN
1
;
Seok Min KIM
;
Jun Young KIM
;
Man Hoon HAN
;
Seok Jong LEE
Author Information
1. Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea. seokjong@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Differential diagnosis;
Microvenular hemangioma;
Multiple;
Kaposi sarcoma
- MeSH:
Actins;
Arm;
Dermis;
Diagnosis, Differential;
Endothelial Cells;
Extremities;
Female;
Hemangioma*;
Humans;
Middle Aged;
Muscle, Smooth;
Negative Staining;
Sarcoma, Kaposi*;
Vascular Neoplasms
- From:Korean Journal of Dermatology
2018;56(10):631-653
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Microvenular hemangioma (MVH) is a rare acquired benign vascular neoplasm, which presents commonly as a solitary purple-to-red nodule or plaque measuring approximately 10 mm in diameter. MVH occurs primarily on the extremities or the trunk. Most lesions are solitary, and multiple lesions are rare. Histopathological features of MVH include numerous, scattered, thin and irregularly branching small vessels in the dermis and endothelial cells without atypia. Owing to similarities in clinical morphology and histopathological features, MVH may often be indistinguishable from the early patch stage of Kaposi sarcoma. Immunohistochemical (IHC) analysis helps differentiate between the 2 diseases. The results of IHC tests in patients with MVH show positive staining for CD31 and smooth muscle actin and typically, negative staining for the human herpes virus 8 antigen. We report a rare case of multiple MVH clinically mimicking the early patch stage of Kaposi sarcoma in a 63-year-old woman who presented with a 3-year history of slowly growing, compressible, soft, bluish-purple macules and plaques on the trunk and right arm.
