Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort.
10.5468/ogs.2018.61.6.662
- Author:
Kyeong A SO
1
;
Seon Ah KIM
;
Yoo Kyung LEE
;
In Ho LEE
;
Ki Heon LEE
;
Jee Eun RHEE
;
Mee Kyung KEE
;
Chi Heum CHO
;
Sung Ran HONG
;
Chang Sun HWANG
;
Mi Seon JEONG
;
Ki Tae KIM
;
Moran KI
;
Soo Young HUR
;
Jong Sup PARK
;
Tae Jin KIM
Author Information
1. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, College of Medicine, Dankook University, Seoul, Korea. kimonc111@naver.com
- Publication Type:Original Article
- Keywords:
Papillomaviridae;
Smoking;
Epidemiology
- MeSH:
Atypical Squamous Cells of the Cervix*;
Cohort Studies*;
Epidemiology;
Female;
Follow-Up Studies;
Human papillomavirus 16*;
Human Papillomavirus DNA Tests;
Humans;
Logistic Models;
Papillomaviridae;
Risk Factors*;
Smoking;
Squamous Intraepithelial Lesions of the Cervix
- From:Obstetrics & Gynecology Science
2018;61(6):662-668
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. RESULTS: Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P < 0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01–17.00). CONCLUSION: The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.
