Comparison of Endothelium-Dependent Vasodilation According to the Presence of Diabetes in Coronary Artery Disease.
10.4070/kcj.2005.35.12.910
- Author:
Jae Woong LEE
1
;
Ui Soon PARK
;
Jin Ho SHIN
;
Kyung Soo KIM
;
Jung Hyun KIM
;
Bang Hun LEE
;
Heon Kil LIM
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicin, Seoul, Korea. limhg@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary artery disease;
Diabetes mellitus;
Endothelium-dependent vasodilation
- MeSH:
Blood Glucose;
Brachial Artery;
Chest Pain;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Diabetes Mellitus;
Endothelium;
Fasting;
Humans;
Ultrasonography;
Vasodilation*
- From:Korean Circulation Journal
2005;35(12):910-915
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The purpose of this study is to evaluate endothelium dependent vasodilation in the diabetic patients suffering with coronary artery disease (CAD). SUBJECTS AND METHODS: 43 patients who presented with typical chest pain and who underwent coronary angiography were enrolled in this study. They were classified into diabetic patients with CAD (n=13), non-diabetic patients with CAD (n=13), diabetic patients without CAD (n=7), and non-diabetic patients without CAD (n=10), according to the presence of CAD and diabetes mellitus. Endothelium-dependent vasodilation of the brachial artery was measured in all the subjects by performing 7.5 MHz high-resolution ultrasound sonography. RESULTS: The endothelium-dependent vasodilation in the diabetic patients with CAD was 1.30+/-2.13% and it was 5.72+/-3.70% in the non-diabetic patients with CAD. There was a significant difference between the two groups (p=0.001). The endothelium-dependent vasodilation in diabetic patients without CAD was 2.28+/-1.88% and it was 10.70+/-10.19% in the non-diabetic patients without CAD. There was a significant difference between the two groups (p=0.029). The endothelium-dependent vasodilations in the diabetic group was 2.28+/-1.88% and it was 10.70+/-10.19% in the non-diabetic group for all the patients. There was a significant difference between the two groups (p=0.029). There was correlation between the endothelium-dependent vasodilation and the fasting blood sugar. There was negative correlation between the endothelium-dependent vasodilation and the fasting blood sugar (FBS) in the patients with CAD (r=-0.59, p=0.002). However, there was no correlation between the endothelium-dependent vasodilation and the FBS in the patients without CAD (r=-0.327, p=0.201). There was negative correlation between the endothelium-dependent vasodilation and the FBS in all subjects (r=-0.352, p=0.021). CONCLUSION: The endothelium-dependent vasodilation was decreased in the diabetic patients with CAD as compared to the non-diabetic patients with CAD. There was also was negative correlation between the endothelium-dependent vasodilation and the FBS in the patients with CAD.
