Antiphospholipid Antibody Positivity and the Clinical Outcomes of Patients with Systemic Lupus Erythematosus.
10.4078/jrd.2018.25.4.239
- Author:
Seoung Wan NAM
1
;
Soo Kyung CHO
;
Dam KIM
;
Kyung Eun LEE
;
Dong Jin PARK
;
Shin Seok LEE
;
Yoon Kyoung SUNG
Author Information
1. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea. sungyk@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Antiphospholipid antibody;
Systemic lupus erythematosus;
Chronic kidney disease
- MeSH:
Antibodies, Antiphospholipid*;
Cerebrovascular Disorders;
Humans;
Lupus Erythematosus, Systemic*;
Lupus Nephritis;
Prevalence;
Renal Insufficiency, Chronic
- From:Journal of Rheumatic Diseases
2018;25(4):239-247
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To identify the prevalence of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients and determine the relationship between aPL and the clinical outcomes. METHODS: SLE patients with aPL test results within 2 years of enrollment were selected from Korean lupus network study. They were classified into two groups: aPL (+) group, patients positive for at least one aPL, and aPL (−) group, patients without an aPL. The clinical characteristics of the two groups were compared and the role of aPL in the risk of chronic kidney disease (CKD) in SLE patients was examined. RESULTS: Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (−) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p < 0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history. CONCLUSION: Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (−) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p < 0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history.
