Association between Serum Uric Acid and Oxidative Stress in Korean Adults.
- Author:
Eun Jeong OK
1
;
Kiyoung KIM
;
Sat Byul PARK
Author Information
- Publication Type:Original Article
- Keywords: Uric Acid; Oxidative Stress; Reactive Oxygen Species; Antioxidants
- MeSH: Adult*; Antioxidants; Female; Humans; Oxidative Stress*; Oxygen; Reactive Oxygen Species; Uric Acid*
- From:Korean Journal of Family Medicine 2018;39(5):295-299
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults. METHODS: The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined. RESULTS: Higher serum UA levels were associated with decreased levels of d-ROMs (P < 0.05). The UA levels were positively associated with BAP levels (P < 0.001). CONCLUSION: Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.
