Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism.
10.3803/EnM.2018.33.3.355
- Author:
Wann Jia LOH
1
;
Dawn Shao Ting LIM
;
Lih Ming LOH
;
Peng Chin KEK
Author Information
1. Department of Endocrinology, Changi General Hospital, SingHealth, Singapore. wann_jia_loh@cgh.com.sg
- Publication Type:Original Article
- Keywords:
Contralateral ratio;
Adrenal venous sampling;
Primary aldosteronism
- MeSH:
Adrenalectomy*;
Catheterization;
Humans;
Hyperaldosteronism*;
Hypertension*;
Hypokalemia;
Retrospective Studies
- From:Endocrinology and Metabolism
2018;33(3):355-363
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates. METHODS: A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed. RESULTS: Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03). CONCLUSION: A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.
