Association between Serum Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Postmenopausal Women.
10.3803/EnM.2018.33.2.273
- Author:
Hoon Sung CHOI
1
;
Hyang Ah LEE
;
Sang Wook KIM
;
Eun Hee CHO
Author Information
1. Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea. ehcho@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Fibroblast growth factor 21;
Postmenopausal women;
Bone density;
Osteoporosis
- MeSH:
Animals;
Body Mass Index;
Bone Density*;
Cohort Studies;
Female;
Femur Neck;
Fibroblast Growth Factors*;
Fibroblasts*;
Hematologic Tests;
Hip;
Humans;
Metabolic Diseases;
Metabolism;
Multivariate Analysis;
Osteocalcin;
Osteoporosis;
Spine
- From:Endocrinology and Metabolism
2018;33(2):273-277
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Despite the beneficial effect of fibroblast growth factor 21 (FGF21) on metabolic disease, there are concerns about adverse effects on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between serum FGF21 level and bone mineral density (BMD) in healthy premenopausal women. We undertook this study to examine the association between FGF21 level and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis. METHODS: We used data of 115 participants from a cohort of healthy postmenopausal women (>50 years old) to examine the association between serum FGF21 level and BMD. The clinical characteristics were obtained from the participants, and blood testing and serum FGF21 testing were undertaken. BMD of the lumbar spine, femoral neck and total hip area, and bone markers were used in the analyses. RESULTS: The mean age of the participants was 60.2±7.2 years. Serum FGF21 levels showed negative correlation with BMD and T-scores in all three areas, but there were no statistically significant differences. Multivariate analyses with adjustment for age and body mass index also did not show significant association between serum FGF21 level and BMD. In addition, serum FGF21 level also showed no correlation with osteocalcin and C-telopeptide levels. CONCLUSION: In our study, serum FGF21 level showed no significant correlation with BMD and T-scores.
