Decrease in intestinal endocrine cells in Balb/c mice with CT-26 carcinoma cells.

Author: Kwang Ho CHO ¹ ; Hyeung Sik LEE ; Sae Kwang KU
Author Information

1. Department of Radiological Science, College of Health Science, Catholic University of Daegu, Daegu 712-702, Korea.
Publication Type:Original Article ; Research Support, Non-U.S. Gov't
Keywords: Balb/c mouse; CT-26; immunohistochemistry; intestinal endocrine cell; tumor
MeSH: Animals; Enteroendocrine Cells/metabolism/*pathology; Female; Gastrointestinal Tract/pathology; Glucagon/metabolism; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental/metabolism/*pathology; Pancreatic Polypeptide/metabolism; Serotonin/metabolism; Sincalide/metabolism; Somatostatin/metabolism
From:Journal of Veterinary Science 2008;9(1):9-14
CountryRepublic of Korea
Language:English
Abstract: The density of intestinal endocrine cells, in Balb/c mice with colon 26 (CT-26) carcinoma cells, were examined immunohistochemically at 28 days after implantation. After CT-26 cell administration there was a significant decrease in most of the intestinal endocrine cells (p < 0.01) compared with the control group. The significant quantitative changes in the intestinal endocrine cell density might contribute to the development of the gastrointestinal symptoms commonly encountered in cancer patients.