Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study.
- Author:
Joon Sung KIM
1
;
Byung Wook KIM
;
Sung Min PARK
;
Ki Nam SHIM
;
Seong Woo JEON
;
Sang Wook KIM
;
Yong Chan LEE
;
Hee Seok MOON
;
Si Hyung LEE
;
Woon Tae JUNG
;
Jin Il KIM
;
Kyoung Oh KIM
;
Jong Jae PARK
;
Woo Chul CHUNG
;
Jeong Hwan KIM
;
Gwang Ho BAIK
;
Jung Hwan OH
;
Sun Moon KIM
;
Hyun Soo KIM
;
Chang Heon YANG
;
Jin Tae JUNG
;
Chul Hyun LIM
;
Hyun Joo SONG
;
Yong Sik KIM
;
Gwang Ha KIM
;
Jie Hyun KIM
;
Jae Il CHUNG
;
Jun Haeng LEE
;
Min Ho CHOI
;
Jong Kyoung CHOI
Author Information
- Publication Type:Original Article
- Keywords: Peptic ulcer hemorrhage; Rebleeding; Risk factors
- MeSH: Hemorrhage*; Humans; Incidence; Korea; Mortality; Multivariate Analysis; Peptic Ulcer Hemorrhage; Peptic Ulcer*; Prospective Studies; Proton Pump Inhibitors; Risk Factors
- From:Gut and Liver 2018;12(3):271-277
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. METHODS: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. RESULTS: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. CONCLUSIONS: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.
