Ceftriaxone-Induced Acute Pancreatitis in Patient with Liver Abscess.
10.15279/kpba.2018.23.2.82
- Author:
Sun Mi KANG
1
;
Jeong Eun SONG
Author Information
1. Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea. songje@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Ceftriaxone;
Pancreatitis;
Biliary sludge;
Pseudolithiasis
- MeSH:
Aged;
Amylases;
Bile;
Ceftriaxone;
Cholangitis;
Cholecystitis;
Dyspepsia;
Fever;
Humans;
Lipase;
Liver Abscess*;
Liver*;
Metronidazole;
Pancreatitis*;
Reference Values
- From:Korean Journal of Pancreas and Biliary Tract
2018;23(2):82-86
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute pancreatitis is a rare complication in patients treated with ceftriaxone. Precipitation of ceftriaxone in the bile causes the formation of biliary sludge leading to the development of cholangitis, cholecystitis, or pancreatitis. We treated a patient with acute pancreatitis who developed this condition after the administration of ceftriaxone. A 70-year-old man presented in a drowsy state with fever. He was diagnosed with a liver abscess and treated with intravenously administrated ceftriaxone and metronidazole. He complained of dyspepsia and epigastric pain on the 25th day of ceftriaxone administration. Laboratory examination and abdominal computed tomography revealed biliary pancreatitis. Ceftriaxone-induced acute pancreatitis was suspected, and ceftriaxone administration was immediately discontinued. Two days later, serum amylase and lipase levels recovered to within reference range, and he showed rapid resolution of symptoms. We concluded that ceftriaxone results in the formation of biliary sludge and causes serious adverse events such as cholecystitis, cholangitis and biliary pancreatitis.
