Follow-up Creatinine Level Is an Important Predictive Factor of In-hospital Mortality in Cirrhotic Patients with Spontaneous Bacterial Peritonitis.
- Author:
Baek Gyu JUN
1
;
Woong Cheul LEE
;
Jae Young JANG
;
Soung Won JEONG
;
Young Don KIM
;
Gab Jin CHEON
;
Yun Nah LEE
;
Sang Gyune KIM
;
Young Seok KIM
;
Young Sin CHO
;
Sae Hwan LEE
;
Hong Soo KIM
Author Information
- Publication Type:Original Article
- Keywords: Liver Cirrhosis; Spontaneous Bacterial Peritonitis; Renal Function; Serum Creatinine Level
- MeSH: Creatinine*; Cytidine Triphosphate; Fibrosis; Follow-Up Studies*; Hepatitis B; Hepatitis C; Hospital Mortality*; Humans; Liver Cirrhosis; Liver Diseases; Male; Medical Records; Multivariate Analysis; Peritonitis*; Retrospective Studies; Sodium; Tertiary Care Centers
- From:Journal of Korean Medical Science 2018;33(12):e99-
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Spontaneous bacterial peritonitis (SBP) is one of the severe complications of liver cirrhosis. Early detection of high-risk patients is essential for prognostic improvement. The aim of this study is to investigate the predictive factors related to in-hospital mortality in patients with SBP. METHODS: This was a retrospective study of 233 SBP patients (181 males, 52 females) who were admitted to four tertiary referral hospitals between August 2002 and February 2013. The patients' laboratory and radiologic data were obtained from medical records. The Child-Turcotte-Pugh (CTP) score and model for end-stage liver disease sodium model (MELD-Na) scores were calculated using the laboratory data recorded at the time of the SBP episode. RESULTS: The causes of liver cirrhosis were hepatitis B (44.6%), alcohol (43.8%), hepatitis C (6.0%), and cryptogenic cirrhosis (5.6%). The mean MELD-Na and CTP scores were 27.1 and 10.7, respectively. Thirty-one of the patients (13.3%) died from SBP in hospital. Multivariate analysis revealed that maximum creatinine level during treatment was a statistically significant factor for in-hospital mortality (P = 0.005). The prognostic accuracy of the maximum creatinine level during treatment was 78.0% (P < 0.001). The optimal cutoff point for the maximum serum creatinine was 2 mg/dL (P < 0.001). CONCLUSION: The follow-up creatinine level during treatment is an important predictive factor of in-hospital mortality in cirrhotic patients with SBP. Patients with SBP and a serum creatinine level during treatment of ≥ 2.0 mg/dL might have a high risk of in-hospital mortality.
