Expression Profile of CircularRNA in Tongue Squamous Cell Carcinoma
- VernacularTitle:舌鳞状细胞癌中环状RNA的表达谱特征
- Author:
Ai-Ling ZOU
1
;
Jian-Jiang ZHAO
;
Xiang SUN
;
Bo JIA
;
Jiu-Song HAN
;
Xiao-Ling QIU
;
Hong-Xing CHU
Author Information
1. 南方医科大学口腔医院∥广东省口腔医院口腔颌面外科
- Keywords:
circle RNA;
tongue squamous cell carcinoma(TSCC);
circRNA microarray
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2018;39(2):186-191,219
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To analyze the expression profile variation of circle RNA(circRNA)in tongue squamous cell carcinoma(TSCC)tissue and para-carcinoma tissue.[Methods]CircRNA microarray technology was performed to in-spect the difference of circRNA expression in 4 cases of TSCC tissues and 4 cases of para-carcinoma tissues,and then make analysis after the quality control and homogenization of raw data,to identify which have more than 2 times variation and significant difference(P<0.05)by statistical analysis as circRNA with differential expression. To perform functional analysis on circRNA with differential expression.[Results]Compared with para-carcinoma tissue,there were 17171 circRNA differentially expressed in TSCC tissue,while 9982 increase more than 2 times and 7189 reduce more than 2 times.[Conclusion]circRNA expression profile in TSCC changes significantly comparing with the para-carcinoma tis-sue,some differentially expressed circRNA may regulate the occurrence and progression of TSCC through a competitive combination of miRNA.
