Progress of relationship between ubiquitinating enzyme damaged-DNA binding protein 2 and tumors
10.3760/cma.j.issn.1006-9801.2018.01.015
- VernacularTitle:泛素化酶DNA损伤特异性结合蛋白2与肿瘤关系的研究进展
- Author:
Huan LING
1
;
Qian ZHOU
;
Yudi XIONG
;
Yunfeng ZHOU
Author Information
1. 430071,武汉大学中南医院肿瘤放化疗科 湖北省肿瘤生物学行为重点实验室
- Keywords:
Neoplasms;
Ubiquitin-protein ligases;
Damaged-DNA binding protein 2;
DDB1 and CUL4-associated factor
- From:
Cancer Research and Clinic
2018;30(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitinating enzyme damaged-DNA binding protein 2 (DDB2) is a rind of DDB1 and CUL4-associated factors (DCAF), and identifies belonging to the family of ubiquitinating E3 enzymes. DDB2 combines with CUL4-DDB1 to form the ubiquitin ligase complex, and identifies targets protein substrate specificity to make the substrate ubiquitin and degradation. It affects the development of tumors through various pathways, such as DNA damage repair, cell cycle regulation and apoptosis, cell invasion and metastasis, cell premature senescence, cell proliferation and cancer stem cell population. This paper reviews the progress of the relationship between DDB2 and the development, treatment and prognosis judgment of tumors.
