Placental growth factor: a useful predictable marker in predicting preeclampsia
10.3760/cma.j.issn.1009-9158.2018.11.018
- VernacularTitle:胎盘生长因子:一项预测子痫前期的重要指标
- Author:
Weiwei SHEN
1
;
Shiming LYU
Author Information
1. 310006 杭州,浙江大学医学院附属妇产科医院生殖遗传教育部重点实验室;浙江省湖州市妇幼保健院产科
- Keywords:
Pre-eclampsia;
Placenta growth factor;
Biomarkers
- From:
Chinese Journal of Laboratory Medicine
2018;41(11):879-882
- CountryChina
- Language:Chinese
-
Abstract:
The placental growth factor ( PlGF) is a kind of glycoprotein with four isoforms , which is predominantly expressed in the placenta . The PlGF plays an important role in the angiogenesis and development , as a biomarker of placenta angiogenesis , the decreasing of the PlGF expression may lead to the dysfunction of vascularization .Anti-angiogenesis is a pathological characteristic of pre-eclampsia.The PlGF levels both in the serum and urine are lower in preeclampsia than those in normal pregnancy .Due to the decreasing of PlGF during the first trimester , the PlGF is an important predictable marker of preeclampsia .It is also expected to be used in the treatment of preeclampsia .
