Recent advances of metabolomics techniques for diagnosis and treatment of kidney disease
10.3760/cma.j.issn.1009-9158.2018.03.014
- VernacularTitle:代谢组学技术在肾脏疾病诊疗中的发展
- Author:
Jiafu FENG
1
Author Information
1. 621000,四川省绵阳市中心医院检验科
- Keywords:
Kidney disease;
Biomarker;
Metabonome/metabolome;
Metabonomics/metabolomics
- From:
Chinese Journal of Laboratory Medicine
2018;41(3):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Kidney disease(KD)is a major challenge for global public healthcare systems. Traditional biomarkers(such as serum creatinine and urea)for measuring kidney function are not sufficient sensitivity and specificity.They are not only affected by many factors,but also were only increase significantly in severe KD.Therefore,more sensitive biomarkers for evaluation of KD is essential. Metabolomics is a promising tool that identify non-targeted,global small-molecule metabolite profiles of complex samples,such as biofluids and tissues extract.The application of metabolomics in KD studies has developed rapidly in the past years.Many benefits have been shown from the use of metabolomics in identifying biomarkers for KD.In particular,metabolomic approaches have the potential to diagnose KD with a higher accuracy than traditional diagnostic methods.Metabolomics in KD research has been expanded from experimental study into clinical applications.
