Progress in pathogenesis of adverse pregnancy outcomes induced by group B Streptococcus

VernacularTitle:B族链球菌感染致不良妊娠结局机制的研究进展
Author: Yu-Qin ZANG ¹ ; Chen WANG ; Wenyan TIAN ; Fengxia XUE
Author Information

1. 300052,天津医科大学总医院妇产科
Keywords: Group B Streptococcus; Vaginal colonization; Ascending infection; Adverse pregnan-cy outcome; Pathogenesis
From: Chinese Journal of Microbiology and Immunology 2018;38(9):716-720
CountryChina
Language:Chinese
Abstract: Group B Streptococcus ( GBS) is a leading infectious cause of adverse pregnancy out-comes such as preterm birth. GBS colonizes the vagina during pregnancy and can ascend into the uterus and then infect the fetus. It encodes a series of virulence factors such as adhesion and invasion factors, hemolytic pigments and hyaluronidase, which are important to vaginal colonization and immune evasion. Immune re-sponses to GBS cause the release of a multiple of inflammatory mediators, leading to the premature rupture of membranes, preterm birth and fetal injury. This paper reviews the pathogenesis of GBS vaginal colonization and ascending infection causing adverse pregnancy outcomes.